Across TCGA patient cohorts, SYN3 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYN3-associated genes across cancer lineages are Caspase-7-cleavedD198, Notch1, and NDRG1_pT346. Each is linked with SYN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SYN3-to-partner and partner-to-SYN3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYN3→partner) and Y-score (partner→SYN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.893	+3.906	<.001	<.001	3	3
UCEC	Notch1 →	+0.191	+1.514	<.001	.015	3	2
SKCM	NDRG1_pT346 →	-0.750	-3.169	.022	.018	3	1
SKCM	PEA-15_pS116 →	-0.315	-2.321	.032	.035	3	1
UCEC	EGFR_pY1068 →	-0.217	-1.584	.011	.032	3	1
UCEC	A-Raf_pS299 →	-0.121	-1.807	.002	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

SYN3 survival (RNA) · tumor vs normal (RNA) · all SYN3 data types