Across TCGA cell cohorts, SYN3 mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYN3-associated genes across cancer lineages are CXCR1, HTN1, and PCDH11Y. Each is linked with SYN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYN3-to-partner and partner-to-SYN3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYN3→partner) and Y-score (partner→SYN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CXCR1 →	+0.079	+3.994	<.001	.002	3	2
URINARY_TRACT	HTN1 →	+0.197	+5.044	<.001	<.001	3	1
URINARY_TRACT	PCDH11Y →	+0.012	+4.087	<.001	.009	3	1
LARGE_INTESTINE	RSPH6A →	+0.110	+3.688	.001	.001	3	1
LARGE_INTESTINE	GALR3 →	+0.081	+3.602	.006	.005	3	1
LARGE_INTESTINE	TSLP →	+0.426	+3.302	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Exploration

SYN3 survival (RNA) · tumor vs normal (RNA) · all SYN3 data types