SYN3-AS1

Across TCGA pan-cancer cohorts, SYN3-AS1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated SYN3-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher SYN3-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SYN3-AS1 expression acts as an unfavorable survival marker, although some lineages such as UVM and KIRC show a favorable association.

UVM, KIRC, and READ are the cancer types where SYN3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.931	0.530	<.001	128	view →
KIRC	DFS	Tertile	All	0.710	0.506	<.001	76	view →
READ	DFS	Tertile	All	0.224	0.647	.001	61	view →
BRCA	OS	Tertile	All	0.957	0.902	.002	46	view →
STAD	DFS	Quartile	II,III,IV	0.233	0.438	.018	38	view →
OV	DFS	Quartile	III,IV	0.448	0.335	.005	38	view →
UCEC	OS	Tertile	All	0.556	0.723	.001	30	view →
SARC	OS	Median	All	0.903	0.781	<.001	30	view →
ACC	OS	Median	All	0.431	0.840	.005	24	view →
BLCA	DFS	Median	All	0.595	0.382	.010	20	view →
UCS	DFS	Median	IV	0.396	0.835	.016	18	view →
DLBC	OS	Tertile	IV	0.367	0.897	.018	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

SYN3-AS1–UVM (DFS)

Open the UVM breakdown →