SYN2

Across TCGA patient cohorts, SYN2 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYN2-associated genes across cancer lineages are SF2, TIGAR, and CD49b. Each is linked with SYN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYN2-to-partner and partner-to-SYN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SF2 grouped by SYN2-low versus SYN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYN2→partner) and Y-score (partner→SYN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SF2 →	-0.104	-1.492	.002	.027	3	2
UCEC	TIGAR →	+0.100	+1.316	.039	.015	3	2
UCEC	CD49b →	-0.264	-2.794	.003	.003	3	2
SKCM	Rictor_pT1135 →	+0.204	+3.017	.021	.019	3	1
SKCM	SCD →	-0.189	-3.000	.023	.036	3	1
SKCM	Bid →	+0.296	+3.000	.002	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

SF2 by SYN2 expression — UCEC

Explore this box plot interactively →