SYN1

Across TCGA pan-cancer cohorts, SYN1 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SYN1 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SYN1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SYN1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC and CCRCC are the cancer types where SYN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	III,IV	0.986	0.575	.019	13	view →
CCRCC	DFS	Median	III,IV	1.000	0.578	.021	4	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SYN1–PDAC (OS)

Open the PDAC breakdown →