SYN1

Across TCGA patient cohorts, SYN1 mutation is significantly associated with the RNA expression of many other genes, with 3,081 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYN1-associated genes across cancer lineages are TYMSP2, DMAC1P1, and HMGN2P8. Each is linked with SYN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYN1-to-partner and partner-to-SYN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TYMSP2 grouped by SYN1-low versus SYN1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYN1→partner) and Y-score (partner→SYN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	TYMSP2 →	+0.212	+6.681	<.001	<.001	3	2
COAD	DMAC1P1 →	+0.256	+2.708	<.001	.004	3	2
COAD	HMGN2P8 →	+0.334	+2.789	<.001	.003	3	2
UCEC	MIR3690 →	+0.222	+1.586	.007	.005	3	2
COAD	NDUFA9 →	+0.452	+3.237	.008	.009	3	2
UCEC	SLC25A4 →	+0.509	+2.332	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,081 associations by consensus.

TYMSP2 by SYN1 expression — READ

Explore this box plot interactively →