SYN1

Across TCGA cell cohorts, SYN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,547 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SYN1-associated GO terms across cancer lineages are Spliceosomal complex assembly, Protein-DNA complex organization, and RNA splicing, via transesterification reactions. Each is linked with SYN1 in more than 9 cancer types. Because this analysis shows association rather than direction, both SYN1-to-partner and partner-to-SYN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spliceosomal complex assembly grouped by SYN1-low versus SYN1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SYN1→partner) and Y-score (partner→SYN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Spliceosomal complex assembly →	+0.074	+1.772	.002	.001	3	10
LUNG_SCLC	Protein-DNA complex organization →	+0.069	+1.759	.001	.008	3	9
UPPER_AERODIGESTIVE_TRACT	RNA splicing, via transesterification reactions →	+0.059	+0.315	.003	.007	2	10
LUNG_SCLC	Nuclear RNA surveillance →	+0.072	+1.421	.001	.006	3	9
UPPER_AERODIGESTIVE_TRACT	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.058	+0.314	.004	.007	2	9
UPPER_AERODIGESTIVE_TRACT	mRNA splicing, via spliceosome →	+0.058	+0.314	.004	.007	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,547 associations by consensus.

Spliceosomal complex assembly by SYN1 expression — LUNG_SCLC

Explore this box plot interactively →