SYMPK

Across TCGA pan-cancer cohorts, SYMPK mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SYMPK’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SYMPK mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SYMPK is over-expressed in tumor.

COAD, LUAD, and LSCC are the cancer types where SYMPK tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SYMPK mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+0.431	<.001	12	view →
LUAD	Male	All	+0.388	<.001	9	view →
LSCC	Male	II,III,IV	+0.556	<.001	8	view →
CCRCC	Male	All	+0.070	<.001	6	view →
OV	All	All	+0.368	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

SYMPK–COAD

Open the COAD breakdown →