SYMPK

Across TCGA patient cohorts, SYMPK mutation is significantly associated with the RNA expression of many other genes, with 3,672 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYMPK-associated genes across cancer lineages are GNPNAT1, ERI1, and IPMK. Each is linked with SYMPK in more than 3 cancer types. Because this analysis shows association rather than direction, both SYMPK-to-partner and partner-to-SYMPK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNPNAT1 grouped by SYMPK-low versus SYMPK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYMPK→partner) and Y-score (partner→SYMPK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GNPNAT1 →	+0.502	+2.402	<.001	<.001	3	4
COAD	ERI1 →	+0.720	+2.598	<.001	.006	3	4
UCEC	IPMK →	+0.354	+1.962	.006	<.001	3	4
UCEC	GPR180 →	+0.356	+1.860	.001	<.001	3	4
UCEC	DCK →	+0.481	+2.201	.002	<.001	3	4
UCEC	GK5 →	+0.403	+1.692	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,672 associations by consensus.

GNPNAT1 by SYMPK expression — UCEC

Explore this box plot interactively →