SYMPK

Across TCGA patient cohorts, SYMPK mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYMPK-associated genes across cancer lineages are ERK2, ACC1, and MEK1. Each is linked with SYMPK in more than 2 cancer types. Because this analysis shows association rather than direction, both SYMPK-to-partner and partner-to-SYMPK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by SYMPK-low versus SYMPK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYMPK→partner) and Y-score (partner→SYMPK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.132	+1.847	.017	.007	3	3
UCEC	ACC1 →	+0.262	+1.347	.012	.006	3	3
UCEC	MEK1 →	+0.295	+1.169	.004	.017	3	3
UCEC	ASNS →	+0.271	+1.999	.009	.008	3	3
COAD	ATM →	-0.715	-3.313	<.001	.010	3	3
UCEC	Claudin-7 →	+0.295	+2.000	.042	.029	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

ERK2 by SYMPK expression — UCEC

Explore this box plot interactively →