SYMPK

Across TCGA cell cohorts, SYMPK RNA expression is significantly associated with the go_rna of many other GO terms, with 3,800 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SYMPK-associated GO terms across cancer lineages are Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, mRNA alternative polyadenylation, and Negative regulation of calcium ion export across plasma membrane. Each is linked with SYMPK in more than 16 cancer types. Because this analysis shows association rather than direction, both SYMPK-to-partner and partner-to-SYMPK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay grouped by SYMPK-low versus SYMPK-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SYMPK→partner) and Y-score (partner→SYMPK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.118	+0.984	<.001	<.001	3	17
STOMACH	mRNA alternative polyadenylation →	+0.109	+1.099	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.086	+0.586	<.001	<.001	3	15
BONE	Negative regulation of DNA-templated transcription, elongation →	+0.133	+0.711	.003	.002	3	15
UPPER_AERODIGESTIVE_TRACT	Nuclear export →	+0.086	+0.680	<.001	<.001	3	14
LARGE_INTESTINE	Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.145	+0.682	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,800 associations by consensus.

Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay by SYMPK expression — STOMACH

Explore this box plot interactively →