SYK

Across TCGA pan-cancer cohorts, SYK Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SYK data layer compared with 23 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher SYK Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SYK expression acts as an unfavorable survival marker.

READ, KIRC, and LGG are the cancer types where SYK Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	III,IV	0.289	0.932	<.001	15	view →
KIRC	OS	Median	II,III,IV	0.170	0.696	.024	12	view →
LGG	OS	Median	All	0.307	0.811	.008	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	OS	Median	III,IV	0.353	0.729	.043	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SYK–READ (OS)

Open the READ breakdown →