SYK

Across TCGA pan-cancer cohorts, SYK mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SYK data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SYK mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SYK expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, PDAC, and HNSC are the cancer types where SYK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	II,III,IV	1.000	0.449	.008	34	view →
PDAC	DFS	Quartile	All	0.537	0.856	.005	11	view →
HNSC	DFS	Median	All	0.860	0.361	.022	10	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
LSCC	OS	Median	II,III,IV	1.000	0.905	.021	6	view →
LUAD	OS	Median	III,IV	0.316	0.714	.036	2	view →
GBM	OS	Tertile	All	0.382	0.595	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SYK–UCEC (OS)

Open the UCEC breakdown →