SYF2

Across TCGA patient cohorts, SYF2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYF2-associated genes across cancer lineages are Ku80, 14-3-3_beta, and EGFR_pY1068. Each is linked with SYF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYF2-to-partner and partner-to-SYF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by SYF2-low versus SYF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYF2→partner) and Y-score (partner→SYF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.469	+3.013	<.001	.019	3	1
UCEC	14-3-3_beta →	-0.130	-2.986	.025	.037	2	1
UCEC	EGFR_pY1068 →	-0.327	-3.000	.024	.037	2	1
UCEC	PCNA →	+0.279	+3.000	.025	.037	2	1
UCEC	TFRC →	+0.748	+3.000	.014	.037	2	1
UCEC	4E-BP1 →	+0.503	+2.837	.001	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Ku80 by SYF2 expression — UCEC

Explore this box plot interactively →