SYDE2

Across TCGA patient cohorts, SYDE2 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYDE2-associated genes across cancer lineages are 14-3-3_beta, ACVRL1, and PDK1. Each is linked with SYDE2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SYDE2-to-partner and partner-to-SYDE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by SYDE2-low versus SYDE2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYDE2→partner) and Y-score (partner→SYDE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	14-3-3_beta →	-0.189	-2.296	.041	.035	3	2
COAD	ACVRL1 →	-0.236	-2.987	.036	.035	2	3
COAD	PDK1 →	-0.106	-2.313	.036	.035	3	2
UCEC	ATM →	-0.526	-1.777	<.001	.002	3	2
COAD	Caspase-7-cleavedD198 →	+1.124	+2.330	.001	.020	3	2
COAD	Di-Ras3 →	-0.215	-2.313	.014	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

14-3-3_beta by SYDE2 expression — COAD

Explore this box plot interactively →