SYDE2

Across TCGA cell cohorts, SYDE2 mutation is significantly associated with the RNA expression of many other genes, with 175 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYDE2-associated genes across cancer lineages are C12orf40, SPAG11A, and RNASE9. Each is linked with SYDE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYDE2-to-partner and partner-to-SYDE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf40 grouped by SYDE2-low versus SYDE2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYDE2→partner) and Y-score (partner→SYDE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	C12orf40 →	+0.026	+3.736	<.001	.007	3	2
LUNG_SCLC	SPAG11A →	+0.710	+3.898	<.001	.005	3	1
LUNG_SCLC	RNASE9 →	+0.019	+4.614	<.001	<.001	3	1
LUNG_SCLC	MS4A13 →	+0.028	+4.058	<.001	.007	3	1
SKIN	NPHS2 →	+0.017	+4.415	<.001	.007	3	1
SKIN	C14orf177 →	+0.015	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 175 associations by consensus.

C12orf40 by SYDE2 expression — LUNG_SCLC

Explore this box plot interactively →