SYDE1

Across TCGA pan-cancer cohorts, SYDE1 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SYDE1 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SYDE1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SYDE1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LSCC and CCRCC are the cancer types where SYDE1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.550	0.839	.009	18	view →
CCRCC	DFS	Quartile	III,IV	0.790	0.449	.012	11	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SYDE1–LSCC (DFS)

Open the LSCC breakdown →