SYDE1

Across TCGA patient cohorts, SYDE1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYDE1-associated genes across cancer lineages are FoxM1, Caspase-7-cleavedD198, and eIF4E. Each is linked with SYDE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SYDE1-to-partner and partner-to-SYDE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SYDE1-low versus SYDE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYDE1→partner) and Y-score (partner→SYDE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.214	+2.247	.024	.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.537	+3.459	.013	.005	3	3
UCEC	eIF4E →	+0.193	+3.183	.012	.009	3	2
UCEC	PKC-delta_pS664 →	-0.105	-2.321	.017	.033	3	2
UCEC	RAD51 →	+0.153	+2.584	.002	.010	3	2
UCEC	ATM →	-0.755	-2.736	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

FoxM1 by SYDE1 expression — UCEC

Explore this box plot interactively →