SYDE1

Across TCGA cell cohorts, SYDE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,428 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SYDE1-associated GO terms across cancer lineages are Actin filament depolymerization, Positive regulation of nitric-oxide synthase activity, and Establishment or maintenance of microtubule cytoskeleton polarity. Each is linked with SYDE1 in more than 14 cancer types. Because this analysis shows association rather than direction, both SYDE1-to-partner and partner-to-SYDE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament depolymerization grouped by SYDE1-low versus SYDE1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SYDE1→partner) and Y-score (partner→SYDE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Actin filament depolymerization →	+0.262	+3.091	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Positive regulation of nitric-oxide synthase activity →	-1.645	-3.859	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Establishment or maintenance of microtubule cytoskeleton polarity →	+0.173	+2.420	<.001	<.001	3	14
STOMACH	Negative regulation of smoothened signaling pathway →	+0.073	+1.681	<.001	.001	3	14
LIVER	Microtubule polymerization →	+0.102	+1.838	.004	.002	3	14
SOFT_TISSUE	Protein depolymerization →	+0.119	+1.342	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,428 associations by consensus.

Actin filament depolymerization by SYDE1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →