SYCP3

Across TCGA pan-cancer cohorts, SYCP3 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SYCP3 data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in sarcoma (SARC), where higher SYCP3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SYCP3 expression acts as an unfavorable survival marker.

SARC, KIRP, and UCEC are the cancer types where SYCP3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SARC	OS	Median	All	0.143	0.745	<.001	6	view →
KIRP	OS	Median	All	0.635	0.903	.027	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SYCP3–SARC (OS)

Open the SARC breakdown →