Across TCGA pan-cancer cohorts, SYCP2 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SYCP2 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SYCP2 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SYCP2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, KIRC, and CHOL are the cancer types where SYCP2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.853	0.617	<.001	36	view →
KIRC	OS	Median	All	0.134	0.811	<.001	30	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
ESCA	OS	Median	All	0.243	0.561	.036	3	view →
LIHC	DFS	Median	III,IV	0.092	0.337	.023	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SYCP2 tumor-vs-normal RNA expression · all SYCP2 data types