Across TCGA pan-cancer cohorts, SYCP1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SYCP1 data layer compared with 16 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SYCP1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SYCP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, LIHC, and ESCA are the cancer types where SYCP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.959	0.826	.015	20	view →
LIHC	OS	Median	All	0.171	0.675	.002	6	view →
ESCA	OS	Median	III,IV	0.136	0.573	.023	6	view →
HNSC	DFS	Median	All	1.000	0.347	.040	3	view →
SKCM	DFS	Median	II,III,IV	0.811	0.659	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SYCP1 tumor-vs-normal RNA expression · all SYCP1 data types