Across TCGA patient cohorts, SYCP1 mutation is significantly associated with the RNA expression of many other genes, with 6,186 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYCP1-associated genes across cancer lineages are SKA1, RNU6-129P, and RPS29P31. Each is linked with SYCP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SYCP1-to-partner and partner-to-SYCP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYCP1→partner) and Y-score (partner→SYCP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA1 →	+0.756	+1.970	<.001	<.001	3	4
HNSC	RNU6-129P →	+0.290	+4.008	<.001	.001	3	3
BLCA	RPS29P31 →	+0.313	+4.255	<.001	<.001	3	3
UCEC	DCP1A →	+0.371	+1.706	.002	.005	3	3
LUSC	C8orf44-SGK3 →	+0.126	+3.242	<.001	.008	3	3
LGG	MIR6877 →	+0.535	+4.680	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,186 associations by consensus.

Exploration

SYCP1 survival (RNA) · tumor vs normal (RNA) · all SYCP1 data types