Across TCGA cell cohorts, SYCP1 mutation is significantly associated with the RNA expression of many other genes, with 200 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYCP1-associated genes across cancer lineages are CCDC166, CD300H, and COX7B2. Each is linked with SYCP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYCP1-to-partner and partner-to-SYCP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYCP1→partner) and Y-score (partner→SYCP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CCDC166 →	+0.040	+3.855	<.001	.007	3	2
LARGE_INTESTINE	CD300H →	+0.020	+3.000	<.001	.003	3	2
SKIN	COX7B2 →	+1.638	+3.584	<.001	.004	3	2
KIDNEY	NOBOX →	+0.026	+5.000	<.001	.005	3	1
KIDNEY	VWC2 →	+0.006	+5.000	<.001	.005	3	1
KIDNEY	OR13C7 →	+0.020	+5.000	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 200 associations by consensus.

Exploration

SYCP1 survival (RNA) · tumor vs normal (RNA) · all SYCP1 data types