SYCE1

Across TCGA patient cohorts, SYCE1 mutation is significantly associated with the RNA expression of many other genes, with 4,665 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYCE1-associated genes across cancer lineages are EIF1AD, RNA5SP394, and COA8. Each is linked with SYCE1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SYCE1-to-partner and partner-to-SYCE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF1AD grouped by SYCE1-low versus SYCE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYCE1→partner) and Y-score (partner→SYCE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EIF1AD →	+0.363	+2.513	<.001	<.001	3	4
CESC	RNA5SP394 →	+0.396	+4.345	<.001	.002	3	3
SKCM	COA8 →	+0.306	+2.577	<.001	<.001	3	3
UCEC	MAIP1 →	+0.359	+1.839	.005	.002	3	3
UCEC	LRR1 →	+0.731	+3.129	<.001	<.001	3	3
UCEC	MRPL16 →	+0.263	+2.078	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,665 associations by consensus.

EIF1AD by SYCE1 expression — UCEC

Explore this box plot interactively →