SYCE1

Across TCGA patient cohorts, SYCE1 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYCE1-associated genes across cancer lineages are PCNA, Src_pY416, and ASNS. Each is linked with SYCE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SYCE1-to-partner and partner-to-SYCE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SYCE1-low versus SYCE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYCE1→partner) and Y-score (partner→SYCE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.309	+2.115	<.001	<.001	3	3
UCEC	Src_pY416 →	-0.175	-1.880	.020	.014	3	3
UCEC	ASNS →	+0.376	+2.115	<.001	.016	3	3
UCEC	Caspase-7-cleavedD198 →	+0.661	+1.945	<.001	.002	3	3
UCEC	Cyclin-E2 →	+0.130	+1.137	.014	.041	3	3
UCEC	Shc_pY317 →	-0.180	-3.700	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

PCNA by SYCE1 expression — UCEC

Explore this box plot interactively →