SYCE1

Across TCGA cell cohorts, SYCE1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SYCE1-associated genes across cancer lineages are OCM2, OR52N1, and MRGPRG. Each is linked with SYCE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYCE1-to-partner and partner-to-SYCE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OCM2 grouped by SYCE1-low versus SYCE1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYCE1→partner) and Y-score (partner→SYCE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OCM2 →	+0.051	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR52N1 →	+0.040	+4.544	.008	.003	3	1
LUNG_NSCLC_LUAD	MRGPRG →	+0.029	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR52L1 →	+0.119	+4.947	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR2W1 →	+0.032	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	PRAMEF11 →	+0.004	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OCM2 by SYCE1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →