SYBU

Across TCGA patient cohorts, SYBU protein abundance is significantly associated with the RNA expression of many other genes, with 8,609 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SYBU-associated genes across cancer lineages are LBR, PLEKHG7, and HCAR1. Each is linked with SYBU in more than 3 cancer types. Because this analysis shows association rather than direction, both SYBU-to-partner and partner-to-SYBU results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SYBU versus LBR in BRCA, with a Pearson correlation of -0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYBU→partner) and Y-score (partner→SYBU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LBR →	-1.024	-0.934	<.001	<.001	3	4
UCEC	PLEKHG7 →	+1.706	+0.744	<.001	<.001	3	4
BRCA	HCAR1 →	+1.234	+0.684	<.001	<.001	3	4
BRCA	SPAG1 →	+1.087	+1.006	<.001	<.001	3	4
OV	DEPTOR →	+1.281	+1.077	<.001	<.001	3	4
UCEC	POC1B →	+1.064	+0.559	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,609 associations by consensus.

SYBU vs LBR — BRCA

Explore this scatter interactively →