SYBU

Across TCGA patient cohorts, SYBU mutation is significantly associated with the RNA expression of many other genes, with 2,953 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYBU-associated genes across cancer lineages are LSP1P1, RNU6-840P, and COMMD9. Each is linked with SYBU in more than 2 cancer types. Because this analysis shows association rather than direction, both SYBU-to-partner and partner-to-SYBU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LSP1P1 grouped by SYBU-low versus SYBU-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYBU→partner) and Y-score (partner→SYBU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LSP1P1 →	+0.229	+3.343	.001	.004	3	3
SKCM	RNU6-840P →	+0.277	+2.434	.004	.004	3	3
UCEC	COMMD9 →	+0.351	+2.295	<.001	<.001	3	3
LUSC	LINC00437 →	+0.169	+3.265	.001	.009	3	3
SKCM	RN7SKP128 →	+0.085	+4.256	<.001	<.001	3	3
UCS	FAM224B →	+0.029	+4.332	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,953 associations by consensus.

LSP1P1 by SYBU expression — BRCA

Explore this box plot interactively →