SYBU

Across TCGA patient cohorts, SYBU mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYBU-associated genes across cancer lineages are eIF4E, ATM, and Caspase-7-cleavedD198. Each is linked with SYBU in more than 2 cancer types. Because this analysis shows association rather than direction, both SYBU-to-partner and partner-to-SYBU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SYBU-low versus SYBU-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYBU→partner) and Y-score (partner→SYBU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.175	+3.335	.013	.005	3	3
UCEC	ATM →	-0.457	-1.584	.002	.009	3	3
UCEC	Caspase-7-cleavedD198 →	+0.559	+1.926	.004	.008	3	3
UCEC	A-Raf_pS299 →	-0.135	-2.321	<.001	.005	3	2
UCEC	JNK2 →	+0.238	+2.916	<.001	<.001	3	2
UCEC	PKC-a →	+0.298	+2.128	.028	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

eIF4E by SYBU expression — UCEC

Explore this box plot interactively →