SYBU

Across TCGA cell cohorts, SYBU mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SYBU-associated genes across cancer lineages are MMP27, FSHR, and CCDC195. Each is linked with SYBU in more than 1 cancer types. Because this analysis shows association rather than direction, both SYBU-to-partner and partner-to-SYBU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP27 grouped by SYBU-low versus SYBU-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYBU→partner) and Y-score (partner→SYBU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MMP27 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	FSHR →	+0.013	+4.906	<.001	.006	3	1
OESOPHAGUS	CCDC195 →	+0.043	+4.906	<.001	.006	3	1
CNS	PYDC1 →	+0.156	+4.754	<.001	.005	3	1
CNS	KRTAP29-1 →	+0.101	+4.643	<.001	.003	3	1
BLOOD_Leukemia	CST8 →	+0.031	+3.969	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

MMP27 by SYBU expression — OESOPHAGUS

Explore this box plot interactively →