SWT1

Across TCGA cell cohorts, SWT1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SWT1-associated genes across cancer lineages are RTL4, TXNDC8, and CPLX4. Each is linked with SWT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SWT1-to-partner and partner-to-SWT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RTL4 grouped by SWT1-low versus SWT1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SWT1→partner) and Y-score (partner→SWT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RTL4 →	+0.006	+5.415	<.001	.004	3	1
SKIN	TXNDC8 →	+0.035	+4.977	<.001	.007	3	1
LARGE_INTESTINE	CPLX4 →	+0.024	+4.392	.004	.004	3	1
LARGE_INTESTINE	PPDPFL →	+0.048	+4.217	<.001	.001	3	1
LARGE_INTESTINE	XKR3 →	+0.050	+3.793	<.001	.007	3	1
OVARY	CD300H →	+0.065	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

RTL4 by SWT1 expression — SKIN

Explore this box plot interactively →