SWAP70

Across TCGA patient cohorts, SWAP70 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SWAP70-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with SWAP70 in more than 1 cancer types. Because this analysis shows association rather than direction, both SWAP70-to-partner and partner-to-SWAP70 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SWAP70-low versus SWAP70-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SWAP70→partner) and Y-score (partner→SWAP70) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.197	+1.847	.013	.008	3	2
UCEC	Caspase-7-cleavedD198 →	+0.624	+2.700	.004	.005	3	2
UCEC	EGFR_pY1068 →	-0.288	-3.392	.001	<.001	3	1
UCEC	EGFR →	-0.214	-2.807	<.001	.003	3	1
UCEC	A-Raf_pS299 →	-0.126	-2.115	.003	.017	3	1
UCEC	HER2_pY1248 →	-0.197	-2.247	.045	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

PCNA by SWAP70 expression — UCEC

Explore this box plot interactively →