SVOPL

Across TCGA pan-cancer cohorts, SVOPL Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SVOPL data layer compared with 21 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher SVOPL Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SVOPL expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ESCA, PRAD, and COAD are the cancer types where SVOPL Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.190	0.707	<.001	33	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
COAD	DFS	Median	All	0.160	0.693	.020	6	view →
UCEC	OS	Median	All	0.973	0.864	.035	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SVOPL–ESCA (OS)

Open the ESCA breakdown →