SVOPL

Across TCGA patient cohorts, SVOPL mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SVOPL-associated genes across cancer lineages are IGFBP2, MEK1, and EGFR_pY1068. Each is linked with SVOPL in more than 1 cancer types. Because this analysis shows association rather than direction, both SVOPL-to-partner and partner-to-SVOPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by SVOPL-low versus SVOPL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SVOPL→partner) and Y-score (partner→SVOPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.828	-2.000	<.001	.003	3	2
UCEC	MEK1 →	+0.317	+2.000	.014	.003	3	2
SKCM	EGFR_pY1068 →	+0.167	+2.824	.020	.034	3	1
SKCM	p70-S6K_pT389 →	+0.199	+2.000	.006	.031	3	1
SKCM	Smad3 →	-0.226	-2.000	.001	.031	3	1
UCEC	Fibronectin →	-0.255	-1.990	.028	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

IGFBP2 by SVOPL expression — UCEC

Explore this box plot interactively →