SVOPL

Across TCGA cell cohorts, SVOPL mutation is significantly associated with the RNA expression of many other genes, with 153 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SVOPL-associated genes across cancer lineages are PGK2, WFDC6, and FGF3. Each is linked with SVOPL in more than 1 cancer types. Because this analysis shows association rather than direction, both SVOPL-to-partner and partner-to-SVOPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGK2 grouped by SVOPL-low versus SVOPL-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SVOPL→partner) and Y-score (partner→SVOPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PGK2 →	+0.209	+4.930	<.001	.008	3	2
LUNG_NSCLC_LUAD	WFDC6 →	+0.050	+4.887	<.001	.009	3	1
CNS	FGF3 →	+0.043	+4.981	<.001	.008	3	1
LARGE_INTESTINE	GCAT →	+1.386	+3.364	<.001	.002	3	1
LARGE_INTESTINE	TRPA1 →	+0.593	+3.362	<.001	.006	3	1
LARGE_INTESTINE	SERAC1 →	+0.624	+3.067	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 153 associations by consensus.

PGK2 by SVOPL expression — SOFT_TISSUE

Explore this box plot interactively →