SVOPL

Across TCGA cell cohorts, SVOPL mutation is significantly associated with the mutation status of many other genes, with 5,237 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SVOPL-associated genes across cancer lineages are SEMA6C, KALRN, and HERC1. Each is linked with SVOPL in more than 4 cancer types. Because this analysis shows association rather than direction, both SVOPL-to-partner and partner-to-SVOPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEMA6C grouped by SVOPL-low versus SVOPL-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SVOPL→partner) and Y-score (partner→SVOPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SEMA6C →	+4.044	+5.000	.008	.008	1	5
SOFT_TISSUE	KALRN →	+2.985	+3.562	.008	.008	1	5
SKIN	HERC1 →	+2.313	+3.282	.007	.007	1	5
LUNG_NSCLC_LUSC	TPTE →	+4.228	+4.228	.004	.004	1	4
SOFT_TISSUE	NFATC4 →	+4.307	+4.307	.001	.001	1	4
SKIN	ZNF516 →	+4.357	+4.053	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,237 associations by consensus.

SEMA6C by SVOPL expression — CNS

Explore this box plot interactively →