Across TCGA patient cohorts, SVIL protein abundance is significantly associated with the RNA expression of many other genes, with 15,732 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SVIL-associated genes across cancer lineages are ASPN, ACTA2, and SPARC. Each is linked with SVIL in more than 9 cancer types. Because this analysis shows association rather than direction, both SVIL-to-partner and partner-to-SVIL results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SVIL→partner) and Y-score (partner→SVIL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ASPN →	+2.534	+0.445	<.001	<.001	3	10
OV	ACTA2 →	+2.205	+0.414	<.001	<.001	3	10
OV	SPARC →	+1.729	+0.397	<.001	<.001	3	10
OV	GLT8D2 →	+1.569	+0.423	<.001	<.001	3	10
OV	PRICKLE1 →	+0.954	+0.362	<.001	.001	3	10
OV	TAGLN →	+1.767	+0.496	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,732 associations by consensus.

Exploration

SVIL survival (RNA) · tumor vs normal (RNA) · all SVIL data types