Across TCGA patient cohorts, SVIL mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SVIL-associated genes across cancer lineages are Smad4, beta-Catenin, and ASNS. Each is linked with SVIL in more than 5 cancer types. Because this analysis shows association rather than direction, both SVIL-to-partner and partner-to-SVIL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SVIL→partner) and Y-score (partner→SVIL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Smad4 →	+0.115	+2.807	.006	.002	3	6
COAD	beta-Catenin →	-0.743	-1.906	<.001	.014	3	5
BRCA	ASNS →	+0.400	+2.459	.016	.021	3	4
COAD	ATM →	-0.468	-2.321	<.001	.004	3	4
BRCA	INPP4B →	-0.631	-3.169	.012	.020	3	3
BRCA	Cyclin-E1 →	+0.466	+3.605	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

Exploration

SVIL survival (RNA) · tumor vs normal (RNA) · all SVIL data types