Across TCGA cell cohorts, SVIL mutation is significantly associated with the RNA expression of many other genes, with 1,074 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SVIL-associated genes across cancer lineages are HDAC1, GRSF1, and CTC1. Each is linked with SVIL in more than 2 cancer types. Because this analysis shows association rather than direction, both SVIL-to-partner and partner-to-SVIL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SVIL→partner) and Y-score (partner→SVIL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HDAC1 →	+0.420	+1.483	.008	.002	3	3
LARGE_INTESTINE	GRSF1 →	+0.415	+1.780	.001	<.001	3	3
LARGE_INTESTINE	CTC1 →	+0.628	+2.000	.002	.004	3	3
LUNG_NSCLC_LUSC	DCD →	+0.046	+4.643	<.001	.008	3	2
SKIN	LCE6A →	+0.265	+4.022	<.001	.006	3	2
SKIN	NUTM1 →	+0.013	+4.459	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,074 associations by consensus.

Exploration

SVIL survival (RNA) · tumor vs normal (RNA) · all SVIL data types