Across TCGA pan-cancer cohorts, SVIL-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated SVIL-AS1 data layer compared with 3 for mutation status.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SVIL-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SVIL-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LGG show a favorable association.

CESC, KIRC, and LIHC are the cancer types where SVIL-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	III,IV	0.181	0.708	<.001	66	view →
KIRC	DFS	Median	All	0.752	0.504	<.001	62	view →
LIHC	OS	Median	All	0.703	0.852	.001	58	view →
BLCA	DFS	Tertile	All	0.461	0.713	.003	51	view →
ACC	DFS	Median	II,III,IV	0.368	0.712	<.001	47	view →
UVM	DFS	Quartile	III,IV	0.193	0.814	.003	43	view →
COAD	DFS	Median	III,IV	0.587	0.744	.008	23	view →
KICH	DFS	Median	II,III,IV	0.564	0.922	.004	20	view →
BRCA	OS	Tertile	II,III,IV	0.486	0.690	.012	20	view →
LGG	OS	Quartile	All	0.944	0.759	<.001	11	view →
ESCA	OS	Tertile	III,IV	0.748	0.413	.010	10	view →
SKCM	DFS	Tertile	All	0.264	0.158	.007	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

Exploration

Same gene, other analysis: SVIL-AS1 tumor-vs-normal RNA expression · all SVIL-AS1 data types