Across TCGA pan-cancer cohorts, SVIL-AS1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SVIL-AS1 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher SVIL-AS1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SVIL-AS1 expression acts as an unfavorable survival marker.

BLCA, STAD, and SKCM are the cancer types where SVIL-AS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.130	0.720	<.001	48	view →
STAD	OS	Median	All	0.003	0.688	<.001	36	view →
SKCM	OS	Median	All	0.374	0.784	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SVIL-AS1 tumor-vs-normal RNA expression · all SVIL-AS1 data types