SVEP1

Across TCGA pan-cancer cohorts, SVEP1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of SVEP1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SVEP1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SVEP1 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, LUAD, and COAD are the cancer types where SVEP1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SVEP1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−0.693	<.001	12	view →
LUAD	Female	II,III,IV	−0.833	<.001	9	view →
COAD	All	III,IV	−0.725	<.001	9	view →
LSCC	Male	III,IV	−1.133	<.001	8	view →
CCRCC	Male	III,IV	−0.758	<.001	6	view →
PDAC	All	All	+0.229	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

SVEP1–HNSC

Open the HNSC breakdown →