SVBP

Across TCGA patient cohorts, SVBP mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SVBP-associated genes across cancer lineages are RNU6-364P, RNA5SP54, and OR4T1P. Each is linked with SVBP in more than 1 cancer types. Because this analysis shows association rather than direction, both SVBP-to-partner and partner-to-SVBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-364P grouped by SVBP-low versus SVBP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SVBP→partner) and Y-score (partner→SVBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-364P →	+0.283	+7.816	<.001	.008	3	1
SKCM	RNA5SP54 →	+0.317	+7.816	<.001	.008	3	1
SKCM	OR4T1P →	+0.039	+7.816	<.001	.008	3	1
SKCM	MIR4309 →	+0.343	+7.816	<.001	.008	3	1
SKCM	MIR4654 →	+0.373	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

RNU6-364P by SVBP expression — SKCM

Explore this box plot interactively →