Across TCGA patient cohorts, SV2B mutation is significantly associated with the RNA expression of many other genes, with 4,538 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SV2B-associated genes across cancer lineages are DSN1, TIAL1, and SKA1. Each is linked with SV2B in more than 2 cancer types. Because this analysis shows association rather than direction, both SV2B-to-partner and partner-to-SV2B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SV2B→partner) and Y-score (partner→SV2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DSN1 →	+0.379	+2.329	.008	.003	3	3
SKCM	TIAL1 →	+0.341	+2.137	.008	.002	3	3
UCEC	SKA1 →	+0.814	+2.688	<.001	<.001	3	3
UCEC	ABHD3 →	+0.465	+3.021	.002	<.001	3	3
UCEC	CIP2A →	+0.600	+1.857	<.001	<.001	3	3
UCEC	POC1A →	+0.500	+2.099	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,538 associations by consensus.

Exploration

SV2B survival (RNA) · tumor vs normal (RNA) · all SV2B data types