SV2B

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SV2B mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SV2B-associated genes across cancer lineages are Caspase-7-cleavedD198, p21, and Bim. Each is linked with SV2B in more than 2 cancer types. Because this analysis shows association rather than direction, both SV2B-to-partner and partner-to-SV2B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SV2B→partner) and Y-score (partner→SV2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECCaspase-7-cleavedD198 →+0.511+1.697.006.01233
SKCMp21 →-0.412-2.115.010.01732
SKCMBim →+0.196+1.765.048.01332
UCECCaspase-8 →-0.208-2.221.008.00132
UCECeIF4E →+0.164+2.598.013.00532
UCECmTOR_pS2448 →-0.136-1.752.003.01132
Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Exploration