Across TCGA cell cohorts, SV2B mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SV2B-associated genes across cancer lineages are MMP26, C18orf63, and ASZ1. Each is linked with SV2B in more than 1 cancer types. Because this analysis shows association rather than direction, both SV2B-to-partner and partner-to-SV2B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SV2B→partner) and Y-score (partner→SV2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MMP26 →	+0.026	+4.807	<.001	.006	3	2
BLOOD_Myeloma	C18orf63 →	+0.013	+4.807	<.001	.006	3	1
LUNG_NSCLC_LUAD	ASZ1 →	+0.345	+2.894	<.001	.004	3	1
LUNG_NSCLC_LUAD	XIRP1 →	+0.018	+3.876	<.001	.003	3	1
LUNG_NSCLC_LUAD	NPY2R →	+0.035	+3.364	<.001	<.001	3	1
LUNG_NSCLC_LUAD	ZCCHC13 →	+0.008	+3.681	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

SV2B survival (RNA) · tumor vs normal (RNA) · all SV2B data types