SV2A

Across TCGA pan-cancer cohorts, SV2A mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SV2A’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where SV2A mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SV2A is over-expressed in tumor.

LSCC, PDAC, and HNSC are the cancer types where SV2A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SV2A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	+1.030	<.001	6	view →
PDAC	All	All	+0.900	.001	4	view →
HNSC	All	All	+0.487	.038	4	view →
LUAD	All	All	+0.613	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SV2A–LSCC

Open the LSCC breakdown →