SV2A

Across TCGA patient cohorts, SV2A RNA expression is significantly associated with the protein abundance of many other proteins, with 22,227 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SV2A-associated proteins across cancer lineages are PCOLCE, DNM1, and VAMP8. Each is linked with SV2A in more than 6 cancer types. Because this analysis shows association rather than direction, both SV2A-to-partner and partner-to-SV2A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SV2A versus PCOLCE in CCRCC, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SV2A→partner) and Y-score (partner→SV2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PCOLCE →	+0.763	+0.506	.001	<.001	3	7
GBM	DNM1 →	+0.603	+0.441	<.001	<.001	3	7
GBM	VAMP8 →	-0.686	-0.551	<.001	<.001	3	6
HNSC	P3H3 →	+0.624	+0.788	.001	.005	3	6
UCEC	UTRN →	+0.355	+0.716	<.001	.001	3	6
HNSC	GSPT1 →	-0.247	-1.167	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,227 associations by consensus.

SV2A vs PCOLCE — CCRCC

Explore this scatter interactively →