SV2A

Across TCGA patient cohorts, SV2A protein abundance is significantly associated with the RNA expression of many other genes, with 9,097 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SV2A-associated genes across cancer lineages are ARHGAP5, SCML2, and C17orf75. Each is linked with SV2A in more than 2 cancer types. Because this analysis shows association rather than direction, both SV2A-to-partner and partner-to-SV2A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SV2A versus ARHGAP5 in LUAD, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SV2A→partner) and Y-score (partner→SV2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ARHGAP5 →	+1.137	+1.878	.004	.003	3	3
LSCC	SCML2 →	+1.171	+0.990	<.001	<.001	3	3
LSCC	C17orf75 →	+1.024	+0.995	<.001	.001	3	3
LUAD	SUDS3 →	+0.780	+1.948	.001	.001	3	3
LUAD	CENPO →	+0.782	+1.046	.002	.008	3	3
LSCC	FAM222A →	+1.122	+1.110	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,097 associations by consensus.

SV2A vs ARHGAP5 — LUAD

Explore this scatter interactively →